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Ultra Omega-3

Ingredients: Purified Marine Triglyceride Concentrate, Vitamin E Mixed Tocopherols, Gelatin, Glycerin and Purified Water.

SUGGESTED USE: 1 soft gel capsule per day or as recommended by your health care professional.

Formulated to be free of allergens derived from: Gluten, corn, yeast, artificial colors and flavors. If you are pregnant or nursing, consult your physician before taking this product. As with all dietary supplements, some individuals may not tolerate or may be allergic to the ingredients used. Please read the ingredient panel carefully prior to ingestion. Cease taking this product and consult your physician if you have negative reactions upon ingestion.

Contraindications, Adverse or Other Reactions: At the recommended dose, few side effects have been reported in the literature. Allergy or sensitivities to fish may occur. Patients using coumadin should use caution.

DISCLAIMER: The information contained on this web site has not been evaluated by the FDA. It is not intended to treat, diagnose, cure or prevent any disease. Material on the Imupharm web site is provided for educational purposes only. Always seek the advice of your physician or other qualified health care provider with any questions you have regarding a medical condition, and before undertaking any diet, exercise or other health program.



Omega 3 Fatty Acids

Essential fatty acids are found in fish, certain seeds, nuts and vegetables (Reference 1). They are essential to human health but cannot be manufactured by the body. For this reason, omega-3 fatty acids must be obtained from food. Omega-3 fatty acids contain eicosapentaeonic acid (EPA) and docosahexaeonic acid (DHA), which are essential for our cardiovascular and immune health. EPA and DHA from fish oil are considered to be the most potent immunomodulatory agents among the fatty acids. (References 3,4)

Immune Health Benefits

Cancer
It has been demonstrated that omega-3 fatty acids can inhibit cell proliferation in human breast (References 6,7,17), colon (References 5,6) pancreatic (Reference 18), and prostate (Reference 8) cancer cells, as well as induce apoptotic cell death.

•   Colorectal Cancer. Consuming significant amounts of foods rich in omega-3 fatty acids appears to reduce the risk of colorectal cancer. For example, Eskimos, who tend to follow a high-fat diet but eat significant amounts of fish rich in omega-3 fatty acids, have a low rate of colorectal cancer. Daily consumption of EPA and DHA also appeared to slow or even reverse the progression of colon cancer in people with early stages of the disease. (References 5,6)

•   Breast Cancer.  Women who regularly consume foods rich in omega-3 fatty acids over many years may be less likely to develop breast cancer. In addition, the risk of dying from breast cancer may be significantly less for those who eat large quantities of omega-3 from fish and brown kelp seaweed (common in Japan) (References 6,7).

•   Pancreatic Cancer. A study has shown that EPA inhibited proliferation of all human pancreatic cancer cell lines in a dose-dependent fashion. Simultalenously, EPA treatment induced apoptosis. (Reference 18)

•   Prostate Cancer. Laboratory and animal studies indicate that omega-3 fatty acids(specifically, DHA and EPA) may inhibit the growth of prostate cancer. (References 8,9)

Cardiovascular benefits

•   Study evaluating fish consumption and the risk of coronary heart disease (CHD) in men, found the risk of CHD is reduced as much as 50% in men who consume 30 grams of fish per day. (Reference 10)

•   11,000 patients surviving a recent myocardial infarction were randomly given 1g/day omega 3 fatty acids, 300mg of vitamin E, both or placebo. The group receiving omega 3 fatty acids had a significantly reduced rate of cardiovascular mortality as early as 3 and 4 months. Dramatic reduction rates in sudden deaths were achieved after 9 months. (Reference 11)

•   Long chain fatty n-3 acids from fish have been shown to be beneficial in lowering triglycerides (Reference 1), the chemical form in which most fat exists in food as well as in the body. A meta-analysis of 65 reports showed triglyceride levels were reduced an average of 25% in those who consumed fish oil (average consumption 4g/day EPA+DHA). (Reference 12)

Additional Cardiovascular benefits (Reference 1)

•   Anti-inflammatory
•   Arterial compliance
•   NO-induced endothelial relaxation
•   Reduced asymmetric dimethyl arginine (ADMA)
•   Reducing atherogenic adhesion molecules
•   Anti-thrombogenic
•   Stabilizing atherosclerotic plaques
•   Peroxisome proliferators-activated receptors (PPAR) regulation.

Anti-inflammatory benefits

•   EPA competes with arachidonic acid (AA) for enzymatic metabolism (COX,LOX), reducing inflammatory responses. (Reference 3)

•   There have been successful results among patients with rheumatoid arthritis using omega-3 fatty acids from fish oil. Meta-analysis data suggest improvements in tender joints and morning stiffness. (Reference 14) The most significant benefits were seen in trials using 2.6 grams/day, 30 mg/kg/day and 40 mg/kg/day. (Reference 1)

Fish oils have also been examined in patients with inflammatory bowel diseases including ulcerative colitis and Crohn’s disease. A number of clinical trials have shown that doses up to 4.5 and 5.4 grams per day have some benefit on preventing relapses, but can reduce the dependence on steroid therapy dramatically. (Reference 15)

Non-Cardiovascular benefits 

•   In a study looking at the correlation between depression and omega-3 fatty acids, a sample of 3,204 adults was examined. Level of depression was estimated with the 21-item Beck Depression Inventory. Mild to severe depressive symptoms were more prevalent among women who consumed fish less than once a week than women who consumed fish more than once a week, a similar trend was observed in men. (Reference 13)

•   Rapid growth of the brain occurs during the last trimester of pregnancy and several months after birth. DHA is crucial for this development, fetal and newborn fatty acid metabolism is inadequate to provide proper levels of DHA. (Reference 1) Maternal supplementation of DHA during the third trimester and while breastfeeding has been shown to improve cognitive development in newborns. (Reference 16)



(1) Guilliams, T. The Use of Fish Oil Supplements in Clinical Practice: A Review. JANA 2005; (8):21-34.

(2) American Heart Association. Home page. Fish and Omega-3 Fatty Acids. [http://www.americanheart.org]

(3) Artemis P. Simopoulos MD. Omega-3 Fatty Acids in Inflammation and Autoimmune Diseases. Journal of the American college of Nutrition. 2002;21(6):495-505.

(4) Kehn P, Fernandes G: The importance of omega-3 fatty acids in the attenuation of immuno-mediated diseases.J Clin Immunol21 :99 –101,2001. [Medline]

(5) Tsai W-S, Nagawa H, Kaizaki S, Tsuruo T, Muto T. Inhibitory effects of n-3 polyunsaturated fatty acids on sigmoid colon cancer transformants. J Gastroenterol . 1998;33:206-212.

(6) de Deckere EAM. Possible beneficial effect of fish and fish n-3 polyunsaturated fatty acids in breast and colorectal cancer. Eur J Cancer Prev . 1999;8:213-221.

(7) Stoll BA. Breast cancer and the Western diet: role of fatty acids and antioxidant vitamins. Eur J Cancer  1998;34(12):1852-1856.

(8) Aronson WJ, Glaspy JA, Reddy ST, Reese D, Heber D, Bagga D. Modulation of omega-3/omega-6 polyunsaturated ratios with dietary fish oils in men with prostate cancer. Urology . 2001;58(2):283-288.

(9) Freeman VL, Meydani M, Yong S, Pyle J, Flanigan RC, Waters WB, Wojcik EM. Prostatic levels of fatty acids and the histopathology of localized prostate cancer. J Urol. 2000;164(6):2168-2172.

(10) Kromhout, D, Bosschieter EB, de Lezenne Couldander C. The inverse relation between fish consumption and 20-year mortality from coronary heart disease. N Engl J Med. 1985; 312(19):1205-1209.

(11) GISSI-Prevenzione Investigators. Dietary Supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Lancet. 1999; 354(9177):447-455.

(12) Harris WS. n-3 fatty acids and serum lipoproteins: human studies. Am J Clin Nutr. 1997; 65(5):1645S-1654S.

(13) Tanskanen A. et al. Fish Consumption and Depressive Symptoms in the General Population in Finland. Psychiatric Services. 2001;52(4):529-531.

(14) Fortin PR, Lew RA et al. Validation of a meta-analysis: the effects of fish oil in rheumatoid arthritis. J Clin Epidemiol. 1995; 48(11):1379-90.

(15) Belluzzi A. N-3 fatty acids for the treatment of inflammatory bowel diseases. Proc Nutr Soc. 2002; 61(3):391-5.

(16) Colombo J, Kannass KN et al. Maternal DHA and the development of attention in infancy and toddlerhood. Child Dev. 2004;75(4):1254-1267.

(17) Mechanisms of omega-3 fatty acid-induced growth inhibition in MDA-MB-231 human breast cancer cells. Schley PD, Jijon HB, Robinson LE, Field CJ. Breast Cancer Res Treat. 2005 Jul;92(2):187-95.

(18) Apoptosis in human pancreatic cancer cells induced by eicosapentaenoic acid. Shirota T, Haji S, Yamasaki M, Iwasaki T, Hidaka T, Takeyama Y, Shiozaki H, Ohyanagi H. Nutrition. 2005 Oct;21(10):1010-7.