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Ultra NK-Stim

Other Ingredients: Natural Vegetable Capsules. This product may contain one or more of the following: Calcium Silicate, Magnesium Stearate, Microcrystalline Cellulose and Silicon Dioxide. TRAACS is a registered trademark of Albion Laboratories, Inc.

SUGGESTED USE: 2 capsules two times per day or as recommended by your health care professional.

Formulated to be free of allergens derived from: Gluten, corn, yeast, artificial colors and flavors. If you are pregnant or nursing, consult your physician before taking this product. As with all dietary supplements, some individuals may not tolerate or may be allergic to the ingredients used. Please read the ingredient panel carefully prior to ingestion. Cease taking this product and consult your physician if you have negative reactions upon ingestion.

Contraindications, Adverse or Other Reactions: Those who are pregnant or nursing should not use Ultra NK-Stim.

DISCLAIMER: The information contained on this web site has not been evaluated by the FDA. It is not intended to treat, diagnose, cure or prevent any disease. Material on the Imupharm web site is provided for educational purposes only. Always seek the advice of your physician or other qualified health care provider with any questions you have regarding a medical condition, and before undertaking any diet, exercise or other health program.



Zinc

Zinc is a trace element involved in many homeostatic mechanisms of the body, including immune response. (Reference 8)

Zinc deficiency can cause impairment of cellular immunity. (Reference 9)

Supplementation with zinc for 1-2 months has been found to restore immune responses and reduce the frequency of infections. (Reference 8)

Arabinogalactan Heartwood

Arabinogalactan is a complex natural polysaccharide that is made up of many galactose and arabinose sugar units linked together in a ratio of 6 galactose units to 1 arabinose unit. It is commonly derived from trees of the Larix genus, including the Western Larch tree (Larix occidentalis) and the Eastern Larch tree (Larix laricina) known as tamarack. It is standardized to provide no less than 85% percent arabinogalactan. (Reference 10)

Studies have shown that arabinogalactan can stimulate Natural Killer (NK) cell cytotoxicity, enhance other functional aspects of the immune system, and support beneficial gut microflora such as Bifidobacteria and Lactobacillus. (References 1,11) It prevented tumor cell colonization of the liver in laboratory animals and may be used as a carrier molecule for hepatocyte directed drug delivery. (Reference 12)

NK cytotoxicity is the ability to mediate spontaneous cytotoxicity against a variety of tumor cells and virus-infected cells without prior sensitization by antigen and restriction by products of the major histocompatibility gene complex. (Reference 1)

Olive Leaf Extract

Olive leaf has a wide number of constituents, including oleuropein and several types of flavonoids, e.g., rutin, apigenin, luteolin. The most active and important element in olive leaf extract is the polyphenol compound oleuropein which is a powerful antioxidant and antiangiogenic agent. (Reference 3) Oleuropein has been shown to have wide-spectrum antibiotic, anti-bacterial, anti-viral and anti-fungal properties. (References 2,3)

A recent test-tube study found that Olive Leaf Extract is inhibiting the proliferation and migration of advanced tumor cell lines. When it was given orally to mice that had developed spontaneous tumors, the extract completely regressed the tumors in 9-12 days. The tumors were cut open before they completely dissolved and researchers noted that they had a crumbly consistency, and that no viable cells could be recovered from them. (Reference 3)

Oleuropein also has been reported to directly stimulate macrophage activation in laboratory studies. (Reference 13)

A study using five ATCC bacterial strains and 44 fresh clinical isolates were tested in-vitro for susceptibility to oleuropein. Oleuropein inhibited the growth of several of the bacterial strains. The researchers concluded that Olea europaea can be considered as an antimicrobial agent for use in intestinal and respiratory tract infections in humans. (Reference 2)

The inhibition of Staphylococcus aureus by oleuropein has been shown to be in large part due to its hydrogen peroxide production. (Reference 4)

Aloe Vera Concentrate

Aloe vera's immune enhancing properties are attributed to the mucopolysaccharides present in the inner gel of the leaf, especially acemannan (acetylated mannan). (Reference 5) An injectable form of acemannan has been approved in the USA as immunostimulant for the treatment of fibrosarcoma in dogs and cats after clincal trials.

Acemannan was administered to female CFW mice that had implanted murine sarcoma cells. The cells grew in 100% of the implanted mice, which typically results in mortality in 20-46 days. Approximately 40% of animals treated with acemannan at the time of tumor cell implantation survived. The data indicated that the acemannan initiated an immune attack on the infected cells. (Reference 6)

The effects of acemannan on mouse macrophage cells was investigated. Acemannan was found to stimulate macrophage cytokine production, nitric oxide release, surface molecule expression, and cell morphologic changes. (Reference 7)



(1) Kelly, G. Larch Arabinogalactan: Clinical Relevance of a Novel Immune-Enhancing Polysaccharide. Alternative Medicine Review. 1999; 4(2)96-103.

(2) Bisignano G, Tomaino A, Lo Cascio R, Crisafi G, Uccella N, Saija A. On the in-vitro activity of oleuropein and hydroxytyrosol. J Pharm Pharmacol. 1999; 51(8):971-4.

(3) Hamdi HK, Castellon R. Oleuropein, a non-toxic olive iridoid, is an anti-tumor agent and cytoskeleton disruptor. Biochem Biophys Res Commun. 2005; 334(3):769-778.

(4) Zanichelli D, Baker TA, Clifford MN, Adams MR. Inhibition of Staphylococcus aureus by oleuropein is mediated by hydrogen peroxide. J Food Prot. 2005;68(7):1492-6.

(5) Sheets MA, Unger BA, Giggleman GF, Tizard IR. Studies of the effect of acemannan on retrovirus infections: clinical stabilization of feline leukemia virus-infected cats. Mol Biother. 1991; 3(1):41-5.

(6) Peng SY, Norman J, Curtin G, Corrier D, McDaniel HR, Busbee D. Decreased mortality of Norman murine sarcoma in mice treated with the immunomodulator, Acemannan. Mol Biother. 1991; 3(2):79-87.

(7) Zhang L, Tizard IR. Activation of a mouse macrophage cell line by acemannan: the major carbohydrate fraction from Aloe vera gel. Immunopharmacology. 1996; 35(2):119-28.

(8) Ferencik M, Ebringer L. Modulatory effects of selenium and zinc on the immune system. Folia Microbiol. 2003;48(3):417-426.

(9) Bogden JD. Influence of zinc on immunity in the elderly. J Nutr Health Aging. 2004; 8(1):48-54.

(10) Larex. Arabinogalactan: Unique physiological benefits. http://www.larex.com

(11) Hauer J, Anderer FA. Mechanism of stimulation of human natural killer cytotoxicity by arabinogalactan from Larix occidentalis. Cancer Immunol Immunother 1993;36:237-244.

(12) Hagmar B, Ryd W, Skomedal H. Arabinogalactan blockade of experimental metastases to liver by murine hepatoma. Invasion Metastasis 1991;11:348-355.

(13) Visioli F, et al. Oleuropein, the bitter principle of olives, enhances nitric oxide production by mouse macrophages. Life Sci. 1998;62(6):541-6.