MILK THISTLE EXTRACT (250 mg capsules) contains Sylimarin, a group of beneficial flavonoids that promote healthy liver function. Research has shown that milk thistle protects your liver naturally from all forms of toxins, supports the body in regenerating healthy liver cells to replace those you've lost. Milk thistle has been studied in laboratory cell lines and animal tumors for its potential to make chemotherapy less toxic and to slow the growth of cancer cells.
Standardized to contain: 80% Silymarin
Suggested for Immune Health and Onco Nutrition
$16 / bottle (100 capsules) 
Other Ingredients: Rice Powder, Dicalcium Phosphate, Gelatin, Vegetable Magnesium Stearate, Silica. FREE OF: artificial color, artificial flavor, artificial sweetener, preservatives, sugar, starch, milk, lactose, soy, gluten, wheat, yeast, fish, sodium.
SUGGESTED USE: For adults, take one (1) capsule three times daily, preferably with meals or follow the advice of your health care professional. Capsules may be opened and prepared as a tea. As a reminder, discuss the supplements and medications you take with your health care providers.
TAMPER RESISTANT: Do not use if seal under cap is broken or missing. KEEP OUT OF REACH OF CHILDREN. Store in a dry place and avoid excessive heat.
WARNING: If you are pregnant, nursing or taking any medications, consult your doctor before use. Avoid this product if you are allergic to ragweed or daisy-like flowers. Discontinue use and consult your doctor if any adverse reactions occur. Not intended for use by persons under the age of 18.
DISCLAIMER: The information contained on this web site has not been evaluated by the FDA. It is not intended to treat, diagnose, cure or prevent any disease. Material on the Imupharm web site is provided for educational purposes only. Always seek the advice of your physician or other qualified health care provider with any questions you have regarding a medical condition, and before undertaking any diet, exercise or other health program.
Milk thistle (Silybum marianum) is an herbal supplement and whose extracts have been recognized for centuries as "liver tonics" and are well-known to prevent or reverse hepatotoxicity of reactive drug metabolites or naturally occurring toxins. (Reference 1, 2) Silymarin, a mixture of flavanoid complexes, is the active component of Milk Thistle that protects liver and kidney cells from toxic effects of drugs, including chemotherapy. Although milk thistle has not significantly altered the course of chronic liver disease, it has reduced liver enzyme levels and demonstrated anti-inflammatory and T cell-modulating effects. There is strong preclinical evidence for silymarin's liver protective and anti-cancer effects, including inhibition of cancer cell growth in human prostate, skin, breast, and cervical cells. (Reference 1)
A number of studies have established the cancer chemopreventive role of silymarin in both in vivo and in vitro models. Silymarin modulates imbalance between cell survival and apoptosis through interference with the expressions of cell cycle regulators and proteins involved in apoptosis. In addition, silymarin also showed anti-inflammatory as well as anti-metastatic activity. Further, the protective effects of silymarin and its major active constituent, silibinin, studied in various tissues, suggest a clinical application in cancer patients as an adjunct to established therapies, to prevent or reduce chemotherapy as well as radiotherapy-induced toxicity. (Reference 3) In a study on the effects of pure flavonolignans from Milk Thistle on the antiproliferative end points in human prostate carcinoma cells, silymarin and silibinin were shown for the first time to suppress the activity of the DNA topoisomerase IIalpha gene promoter in DU145 cells. The findings suggest that extracts enriched for isosilybin B (a pure flavonolignan compound isolated from commercial silymarin extracts), or isosilybin B alone, might possess improved potency in prostate cancer prevention and treatment. (Reference 4)
Milk thistle is considered safe and well-tolerated, with gastrointestinal upset, a mild laxative effect, and rare allergic reaction being the only adverse events reported when taken within the recommended dose range. (Reference 1)
(1) Post-White J, Ladas EJ, Kelly KM. Advances in the use of milk thistle (Silybum marianum). Integr Cancer Ther. 2007 Jun;6(2):104-9.
(2) Kroll DJ, Shaw HS, Oberlies NH. Milk thistle nomenclature: why it matters in cancer research and pharmacokinetic studies. Integr Cancer Ther. 2007 Jun;6(2):110-9.
(3) Ramasamy K, Agarwal R. Multitargeted therapy of cancer by silymarin. Cancer Lett. 2008 Oct 8;269(2):352-62. Epub 2008 May 9.
(4) Davis-Searles PR, Nakanishi Y, Kim NC, Graf TN, Oberlies NH, Wani MC, Wall ME, Agarwal R, Kroll DJ. Milk thistle and prostate cancer: differential effects of pure flavonolignans from Silybum marianum on antiproliferative end points in human prostate carcinoma cells. Cancer Res. 2005 May 15;65(10):4448-57.