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Advanced Integrative Immunotherapy for Cancer







Other ingredients: Whey protein concentrate, ISO malt, oat bran, rice bran, psyllium husks, raspberry flavor, silicone dioxide, Stevia

SUGGESTED USE: As a dietary supplement, take one (1) level scoop mixed with desired cold liquid up to four (4) times daily or as directed by your health care professional.

DISCLAIMER: The information contained on this web site has not been evaluated by the FDA. It is not intended to treat, diagnose, cure or prevent any disease. Material on the Imupharm web site is provided for educational purposes only. Always seek the advice of your physician or other qualified health care provider with any questions you have regarding a medical condition, and before undertaking any diet, exercise or other health program.

Proprietary Mushroom Blend

There are an estimated 140,000 mushroom species on Earth, yet there are only 14,000 named species know. These comprise a vast and largely untapped source of powerful pharmaceutical products. In particular, they represent an unlimited source of polysaccharides with antitumor and immunostimulating properties. Mushroom polysaccharides prevent oncogenesis, show direct antitumor activity against various allogeneic and syngeneic tumors, and prevent tumor metastasis. Polysaccharides from mushrooms do not attack cancer cells directly, but produce their antitumor effects by activating different immune responses in the host. (Reference 1)

Ganoderma lucidum

The antiproliferative activities on tumoral cells, namely, human breast cancer (MCF-7 and MDA-MB-231), hepatoma (HepG2) and myeloid leukemia (HL-60), of ethanolic extracts from two species of Ganoderma, G. lucidum and G. sinense, were investigated. Both had apoptosis induction through the alternation of mitochondrial transmembrane depolarization, though no triterpenoids were detected in ethanolic extract of G. sinense. Furthermore, the two extracts from G. lucidum and G. sinense could arrest cell cycle at different phases. This study showed that ethanol extracts of both G. lucidum and G. sinense have antitumoral proliferation effect through both apoptosis pathway and cell cycle arrest effect, and some other compounds such as sterols and/or nucleosides may contribute to their activity besides triterpenoids. (Reference 2)

A study was conducted where in structurally related lanostane-type triterpenes, ganoderic acid A, F and H (GA-A, GA-F, GA-H), were identified in an oriental medicinal mushroom Ganoderma lucidum. The effect of GA-A, GA-H and GA-F on highly invasive human breast cancer cells was evaluated. It was shown that GA-A and GA-H suppressed growth (cell proliferation and colony formation) and invasive behavior (adhesion, migration and invasion) of MDA-MB-231 cells. Results suggest that GA-A and GA-H mediate their biological effects through the inhibition of transcription factors AP-1 and NF-kappaB, resulting in the down-regulation of expression of Cdk4 and the suppression of secretion of uPA, respectively. Furthermore, the activity of ganoderic acids is linked to the hydroxylation in the position 7 and 15 (GA-A) and 3 (GA-H) in their triterpene lanostane structure. In conclusion, hydroxylated triterpenes from G. lucidum could be promising natural agents for the therapy of invasive breast cancers. (Reference 3)

Lentinus edodes

Lentinan, the polysaccharides extracted from this kind of black mushroom shiitake, has been clinically applied as an antitumor and antimetastatic drug and is sold widely in Japan. It has been reported to prevent both chemical and viral carcinogenesis. (Reference 4, 5) It has also been shown to maintain its antitumor property with oral administration. (Reference 6)

Grifola frondosa

TThe tumoricidal activity of a bioactive metabolite produced by submerged culture in a 2.1-L airlift fermentor of Grifola frondosa NTUS was investigated. After 14 days of cultivation, ethyl acetate extracts from the supernatant of culture broth (EES) were analyzed by cell viability assay. The IC50 of EES for cytotoxicity against human carcinoma cells (Hep 3B, Hep G2, HeLa, CL1-1) and normal human lung fibroblast MRC-5 was 78.4, 52.7, 77.6, 71.0, and 233.3 microg/mL, respectively. EES was further fractionated and a main cytotoxic compound, HE-5-5, was obtained. The IC50 of HE-5-5 based on the cell viability of Hep 3B and MRC-5 cells was 3.6 and 33.1 microg/mL, respectively. Thus, HE-5-5 showed a selective cytotoxic effect against Hep 3B cells and MRC-5. According to the UV, MS, and NMR data, HE-5-5 was identified as o-orsellinaldehyde. A DNA fragmentation assay together with the presence of a significant sub-G1 peak by flow cytometry suggested that o-orsellinaldehyde might mediate its cytotoxicity through apoptosis. (Reference 7)

The biological function of GFPPS1b, a novel polysaccharide-peptide isolated from cultured mycelia of Grifola frondosa GF9801, was well investigated. GFPS1b has anti-tumor activity and can significantly inhibit the proliferation of SGC-7901 cells, whereas slightly influences the growth of human normal liver cell line L-02. The finding suggests that GFPS1b could suppress SGC-7901 cell growth and reduce cell survival via arresting cell cycle and inducing apoptosis of tumor cells. (Reference 8)

Coriolus versicolor

Protein-bound polysaccharide (PSK) is derived from the CM-101 strain of the fungus Coriolus versicolor and has shown anticancer activity in vitro and in in vivo experimental models and human cancers. Several randomized clinical trials have demonstrated that PSK has great potential in adjuvant cancer therapy, with positive results in the adjuvant treatment of gastric, esophageal, colorectal, breast and lung cancers. These studies have suggested the efficacy of PSK as an immunomodulator of biological responses. The in vitro cytotoxic anti-tumour activity of PSK has been evaluated in various tumour cell lines derived from leukaemias, melanomas, fibrosarcomas and cervix, lung, pancreas and gastric cancers. Tumour cell proliferation in vitro was measured by BrdU incorporation and viable cell count. Effect of PSK on human peripheral blood lymphocyte (PBL) proliferation in vitro was also analyzed. Studies of cell cycle and apoptosis were performed in PSK-treated cells. PSK showed in vitro inhibition of tumour cell proliferation as measured by BrdU incorporation and viable cell count. The inhibition ranged from 22 to 84%. Inhibition mechanisms were identified as cell cycle arrest, with cell accumulation in G0/G1 phase and increase in apoptosis and caspase-3 expression. These results indicate that PSK has a direct cytotoxic activity in vitro, inhibiting tumour cell proliferation. In contrast, PSK shows a synergistic effect with IL-2 that increases PBL proliferation. These esults indicate that PSK has cytotoxic activity in vitro on tumour cell lines. This new cytotoxic activity of PSK on tumour cells is independent of its previously described immunomodulatory activity on NK cells. (Reference 9)

Tremella fuciformis

Four kinds of acidic heteroglycan, T3a-T3d, isolated from the body of the fungus Tremella fuciformis Berk, were able to induce human monocytes to produce interleukin-1, interleukin-6, and tumor necrosis factor in vitro. (Reference 10)

Cordyceps sinensis

Cordyceps sinensis (Cs) is a well-known traditional Chinese medicine, possesses activities in anti-tumor, anti-oxidation and stimulating the immune response, and has been used there as a treatment for a variety of conditions, including neoplasms. The available evidence suggests that efficacy of Cs as an anti-neoplastic therapeutic agent is related to a role as an activator of innate immune responses. It was found that oral Cs can reduce lung metastasis occurrence in a surgical excision model of metastatic mammary carcinoma. (Reference 11, 12)

An exo-polysaccharide was isolated from a strain of Cordyceps sinensis (UST 2000), called cordysinocan. It contains glucose, mannose, galactose in a ratio of 2.4:2:1. In cultured T-lymphocytes, application of cordysinocan induced the cell proliferation and the secretion of interleukin-2, interleukin-6 and interleukin-8. In addition, the phosphorylation of extracellular signal-regulated kinases (ERK) was induced transiently by the treatment of cordysinocan. Moreover, application of cordysinocan in cultured macrophages increased the phagocytosis activity and the enzymatic activity of acid phosphatase. These results therefore verify the important role of Cordyceps polysaccharide in triggering such immune responses. (Reference 12)

Agaricus blazei

Agaricus blazei is widely accepted as a traditional medicinal mushroom, which has been known to exhibit immunostimulatory and anti-cancer activity. It was observed that ABE-induced apoptosis is associated with the mitochondrial pathway, which is mediated by reactive oxygen species (ROS) generation and prolonged c-Jun N-terminal kinase (JNK) activation. The study has shown that ABE induces apoptosis with ROS-dependent JNK activation and constitutive activated NF-kappaB inhibition in THP-1 cells. (Reference 13)

Another study has also shown possibility that A. blazei extracts can be useful in inflammatory diseases because of activation of the immune system and its cells induced by the presence of polysaccharides such as beta-glucans. (Reference 14)


Vitamins, Minerals and Herbal Substances

In addition to their many vital functions, select vitamins, minerals and herbs have antioxidant properties. Antioxidants are substances that can protect cells from the damage caused by free radicals (molecules with a non-paired electron, which are natural by-products of metabolic functioning). Free radical damage may lead to cancer. Extensive laboratory findings from chemical, cell culture, and animal studies indicate that antioxidants stabilize free radicals and may prevent the development of cancer. Examples of antioxidants include vitamins A, C, E, Beta-Carotene, Lycopene, Coenzyme Q10 and other substances.

Select vitamins, minerals and herbs provide not only antioxidant benefits but also modulate the immune functions on the humoral and cellular levels. Numerous research studies have indicated the immune modulatory effect of natural substances such as Andrographis Paniculata, Turmeric, Panex Ginseng, Lycopene, Grape Seed Extract, Germanium Sesquioxide, Bioflavenoid Complex, Green Tea Extract, Selenium, Co-enzyme Q10, Alpha and Beta Carotene, N-acetyl Cysteine, Glutathione, Selenium, and others, the more so, when they work in synergy. Herbal supplements are proven powerful antioxidants especially when assisting other nutrients.

Andrographis paniculata

Andrographis paniculata plant extract is known to possess a variety of pharmacological activities. Andrographolide, the major constituent of the extract is implicated towards its pharmacological activity. Andrographolide treatment inhibited the in vitro proliferation of different tumor cell lines, representing various types of cancers. The compound exerts direct anticancer activity on cancer cells by cell-cycle arrest at G0/G1 phase through induction of cell-cycle inhibitory protein p27 and decreased expression of cyclin-dependent kinase 4 (CDK4). Immunostimulatory activity of andrographolide is evidenced by increased proliferation of lymphocytes and production of interleukin-2. Andrographolide also enhanced the tumor necrosis factor-α production and CD marker expression, resulting in increased cytotoxic activity of lymphocytes against cancer cells, which may contribute for its indirect anticancer activity. The in vivo anticancer activity of the compound is further substantiated against B16F0 melanoma syngenic and HT-29 xenograft models. These results suggest that andrographolide is an interesting pharmacophore with anticancer and immunomodulatory activities and hence has the potential for being developed as a cancer therapeutic agent. (Reference 15)

Vitamin A

    • Vitamin A is a fat-soluble vitamin also known as retinol. Most people are familiar with vitamin A’s role in preventing night blindness.
    • Vitamin A is a stimulator for the thymus and plays a large role in maintaining the function of the immune system.
    • Vitamin A boosts white blood cell function and increases antibody response. (Reference 16)

Vitamin B

The Vitamins B are essential to the enzymatic processes in the liver. Along with the addition of Choline, N-acetyl Cysteine, Glutathione, Taurine, MSM and Sulphoraphane they enhance detoxifaction and elimination.

Vitamin C

    • Vitamin C improves antimicrobial and natural killer cell activities. (Reference 17) It enhances overall immune functions.
    • The effectiveness of high doses of Vitamin C intravenously against cancer has been shown by researchers of the National Institutes of Health, Bethesda, MD. (Reference 18)
    • In another study 168 volunteers were randomized to receive a placebo or vitamin C tablets daily over a 60-day time frame between November and February. The group that received the vitamin C had fewer colds, fewer days challenged virally, and a shorter duration of severe symptoms. Volunteers in the vitamin C group were less likely to get a cold and recovered faster. (Reference 19)

Vitamin E is a fat-soluble antioxidant that stops the production of reactive oxygen species ROS formed when fat undergoes oxidation. The body forms ROS endogenously when it converts food to energy, and antioxidants might protect cells from the damaging effects of ROS. Scientists are investigating whether, by limiting free-radical production and possibly through other mechanisms, vitamin E might help prevent or delay the chronic diseases associated with free radicals.

In addition to its activities as an antioxidant, vitamin E is involved in immune function and, as shown primarily by in vitro studies of cells, cell signaling, regulation of gene expression, and other metabolic processes. (Reference 20) Alpha-tocopherol inhibits the activity of protein kinase C, an enzyme involved in cell proliferation and differentiation in smooth muscle cells, platelets, and monocytes. Vitamin-E-repleted endothelial cells lining the interior surface of blood vessels are better able to resist blood-cell components adhering to this surface. Vitamin E also increases the expression of two enzymes that suppress arachidonic acid metabolism, thereby increasing the release of prostacyclin from the endothelium, which, in turn, dilates blood vessels and inhibits platelet aggregation. (Reference 21)

Selenium is an essential nonmetal trace element that has been shown to be very important for immune health. A study revealed that higher serum selenium was associated with lower prostate cancer risk. (Reference 22)

N-Acetyl Cysteine is easily converted in the body to Glutathine, which is a vital antioxidant. It replenishes intracellular Glutathione (GSH) levels and is considered a safe, well-tolerated antidote for cysteine/GSH deficiency. NAC has been used successfully to treat GSH deficiency in a wide range of infections, genetic defects and metabolic disorders, including HIV infection and COPD. (Reference 23)

N-Acetyl Cysteine, also known as NAC, is an amino acid supplement. Amino acids are the building blocks of protein and intermediates in metabolism. There are 20 amino acids found within proteins, and the human body can produce only 10 of these, including cysteine. As the body does not store excess amino acids for later use; it is essential to obtain them in one’s daily diet. (Reference 24)

Thiol antioxidants, typified by N-acetyl cysteine, have been found to induce p53-dependent apoptosis in human cells. (Reference 25) Another study has shown a favorable effect of NAC on several important T-cell functions in vitro in advanced-stage cancer patients. (Reference 26)

N-acetylcysteine (NAC) is widely used as a mucolytic agent as it helps dissolve thick mucus and relieve respiratory difficulties. It provides the sulfhydryl groups and acts both as a precursor of reduced glutathione and as a direct reactive oxygen species (ROS) scavenger, hence regulating the redox status in the cells. (References 27, 28)

Green Tea Leaf (Extract) Rich in polyphenols, which contain potent anti-oxidant and anti-cancer properties; helps protect against cancer; lowers cholesterol levels; reduces the clotting tendency of the blood; stimulates the immune system; helps regulate blood sugar and insulin levels; combats mental and physical fatigue; helps prevent atherosclerosis; prevents an enlarged prostate; used in weight-loss programs. (References 29, 30, 31)

Inositol hexaphosphate (IP6) is a naturally occurring polyphosphorylated carbohydrate that is present in substantial amounts in almost all plant and mammalian cells. It was recently recognized to possess multiple biological functions. A striking anticancer effect of IP6 was demonstrated in different experimental models. Inositol is also a natural constituent possessing moderate anticancer activity. The most consistent and best anticancer results were obtained from the combination of IP6 plus inositol. In addition to reducing cell proliferation, IP6 increases differentiation of malignant cells, often resulting in a reversion to normal phenotype. Exogenously administered IP6 is rapidly taken into the cells and dephosphorylated to lower-phosphate inositol phosphates, which further interfere with signal transduction pathways and cell cycle arrest. Enhanced immunity and antioxidant properties can also contribute to tumor cell destruction. However, the molecular mechanisms underlying this anticancer action are not fully understood. (Reference 32)


Glutathione (gamma-L-glutamyl-L-cysteinyl-glycine) is a peptide (short protein)-like molecule synthesized in the body from the three amino acids L-glutamic acid, L-cysteine, and glycine. Glutathione is one of the body’s most important and powerful antioxidants, helping to detoxify xenobiotics. A major function of vitamin C is to keep glutathione in its reduced form so that they can continue to provide free radical quenching effects. (Reference 33, 34)

Olive Leaf Extract

A recent test-tube study found that Olive Leaf Extract is a powerful antioxidant and anti-cancer agent, inhibiting the proliferation and migration of advanced tumor cell lines. When it was given orally to mice that had developed spontaneous tumors, the extract completely regressed the tumors in 9-12 days. The tumors were cut open before they completely dissolved and researchers noted that they had a crumbly consistency, and that no viable cells could be recovered from them. This study provides hope that Olive Leaf Extract can be developed into a potent anti-tumor medicinal, and may explain the cancer-protective effects of the olive-rich Mediterranean diet. (Reference 35)

Grape Seed Extract

Grape seed extract is the primary commercial source of oligomeric proanthocyanidins (OPCs), a group of powerful antioxidants, which is also called pycnogenol, a class of flavonoids. Labor Laboratory studies have indicated OPCs are much more effective than vitamin C and vitamin E in neutralizing free oxygen radicals, which contribute to organ degeneration and aging in humans. (Reference 36)

OPCs have also been reported to demonstrate antibacterial, antiviral, anticarcinogenic, anti-inflammatory, anti-allergic, and vasodilatory actions. In addition, they have been found to inhibit lipid peroxidation, platelet aggregation, capillary permeability and fragility, and to affect enzyme systems including phospholipase A2, cyclooxygenase, and lipoxygenase. (Reference 37)


Lycopene is a carotenoid present in tomatoes, processed tomato products and other fruits. It is one of the most potent antioxidants among dietary carotenoids. Dietary intake of tomatoes and tomato products containing lycopene has been shown to be associated with a decreased risk of chronic diseases, such as cancer and cardiovascular disease. Serum and tissue lycopene levels have been observed to be inversely related to the incidence of prostate, pancreas and stomach cancers. In some of the studies lycopene was the only carotenoid associated with risk reduction. (Reference 38)


Curcumin is a polyphenol and the active ingredient of the spice, turmeric (Curcuma longa Linn), which is derived from the plant’s rhizomes. It has been shown to be a potent antioxidant and anti-inflammatory agent. Extensive research over the last 50 years has indicated that curcumin can both prevent and treat cancer. The activity of curcumin reported against leukemia and lymphoma, gastrointestinal cancers, genitourinary cancers, breast cancer, ovarian cancer, head and neck squamous cell carcinoma, lung cancer, melanoma, neurological cancers, and sarcoma reflects its ability to affect multiple targets. (Reference 39)

Coenzyme Q10

Coenzyme Q10 (also known as CoQ10, Q10, vitamin Q10, ubiquinone, and ubidecarenone) is a benzoquinone compound synthesized naturally by the human body. Coenzyme Q10 is used by cells of the body in a process known variously as aerobic respiration, aerobic metabolism, oxidative metabolism, or cell respiration. Through this process, energy for cell growth and maintenance is created inside cells in compartments called mitochondria. Coenzyme Q10 is also used by the body as an endogenous antioxidant. (Reference 40)

In patients with cancer, coenzyme Q10 has been shown to protect the heart from anthracycline-induced cardiotoxicity (anthracyclines are a family of chemotherapy drugs, including doxorubicin, that have the potential to damage the heart) and to stimulate the immune system. Stimulation of the immune system by this compound has also been observed in animal studies and in humans without cancer. In part because of its immunostimulatory potential, coenzyme Q10 has been used as an adjuvant therapy in patients with various types of cancer. (Reference 40)

Germanium sesquioxide

Germanium sesquioxide induces interferon-gamma, enhances natural killer cell activity, and inhibits tumor and metastatic growth. (Reference 41)

In a study of a patient with pulmonary spindle cell carcinoma who self-medicated herself with daily doses of germanium, there was noted prompt symptomatic improvement and remains clinically and radiographically free of disease 42 months after starting her alternative therapy. (Reference 42)


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