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Estroglucarate Plus

SUGGESTED USE: 2 capsules per day or as recommended by your health care professional.

Formulated to be free of allergens derived from: Gluten, corn, yeast, artificial colors and flavors. Contains soy. Do not consume this product if you are pregnant or nursing. Consult your physician for further information. As with all dietary supplements, some individuals may not tolerate or may be allergic to the ingredients used. Please read the ingredient panel carefully prior to ingestion. Cease taking this product and consult your physician if you have negative reactions upon ingestion.

DISCLAIMER: The information contained on this web site has not been evaluated by the FDA. It is not intended to treat, diagnose, cure or prevent any disease. Material on the Imupharm web site is provided for educational purposes only. Always seek the advice of your physician or other qualified health care provider with any questions you have regarding a medical condition, and before undertaking any diet, exercise or other health program.


Calcium-D-glucarate is the calcium salt of D-glucaric acid, a substance produced naturally in small amounts by mammals, including humans. Glucaric acid is also found in many fruits and vegetables with the highest concentrations to be found in oranges, apples, grapefruit, and cruciferous vegetables. (Reference 2)  

Oral supplementation of Calcium-D-glucarate has been shown to inhibit elevated beta-glucuronidase activity which is associated with an increased risk for various cancers, particularly hormone dependent cancers such as breast and prostate cancers, as well as colon cancers. (Reference 1) The calcium-D-glucarate delivered by Estroglucarate Plus is capable of inhibiting this glucuronidase activity and reducing the harmful burden on the body.


Human clinical trials show an improvement in 2/16 hydroxy-estrone ratios in women taking Indole-3-Carbinol (I3C), demonstrating its value in helping lower cancer risk in these women.

I3C is considered one of the main active ingredients accounting for the health benefits found in cruciferous vegetables. Indol-3-Carbinol, and many of its metabolites including diindolylmethane (DIM), have been investigated with in vitro and animal studies using susceptible cell and animal lines.

Indole-3-carbinol has a number of potential mechanisms of action for chemoprevention of cancer. It was one of only eight compounds (including ascorbic acid, vitamin E succinate, and folic acid) found to have benefit in six different in vitro chemoprevention models in a National Cancer Institute screening study. (Reference 3) While many mechanisms have been described, it is possible others exist, particularly among the minor I3C metabolites that have not been well studied.

Several studies have examined the effects of I3C and its metabolites on breast cancer cell lines. I3C can stimulate apoptosis in estrogen receptor-negative human breast cancer cell lines as well. (References 4,5,6)  Indol-3-Carbinol has also shown to induce apoptosis in other human cancer cells. (Reference 7)

Vitamin E 

Vitamin E is a powerful antioxidant that boosts the immune system and contributes to the prevention of tumor blood vessel growth according to scientific studies.

Folic Acid

The proper processing of estrogen metabolites requires folic acid. Folic acid deficiency, especially alcohol-related, increases risk for estrogen-related conditions.

1. Walaszek Z, Szemraj J, Narog M, et al. Metabolism, uptake, and excretion of a D-glucaric acid salt and its potential use in cancer prevention. Cancer Detect Prev 1997;21:178-190.

2. Dwivedi C, Heck WJ, Downie AA, et al. Effect of calcium glucarate on beta-glucuronidase activity and glucarate content of certain vegetables and fruits. Biochem Med Metab Biol 1990;43:83-92.

3. Sharma S, Stuzman JD, Kelloff GJ, Steele VE. Screening of potential chemopreventive agents using biochemical markers of carcinogenesis. Cancer Res 1994;54:5848-5855.

4. Cover CM, Hsieh SJ, Cram EJ, et al. Indole-3-carbinol and tamoxifen cooperate to arrest the cell cycle of MCF-7 human breast cancer cells. Cancer Res 1999;59:1244-1251.

5. Telang NT, Katdare M, Bradlow HL, et al. Inhibition of proliferation and modulation of estradiol metabolism: novel mechanisms for breast cancer prevention by the phytochemical indole-3-carbinol. Proc Soc Exp Biol Med 1997;216:246-252.

6. Chen I, McDougal A, Wang F, Safe S. Aryl hydrocarbon receptor-mediated antiestrogenic and antitumorigenic activity of diindolylmethane. Carcinogenesis 1998;19:1631-1639.

7. Ge X, Yannai S, Rennert G, et al. 3,3'-diindolylmethane induces apoptosis in human cancer cells. Biochem Biophys Res Commun 1996;228:153-158.