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Modified Citrus Pectin

Other Ingredients: Highly refined soybean oil, Gelatin, Glycerin, Water.

SUGGESTED USE: Take one softgel daily or as directed by your healthcare practitioner. Do not exceed recommended dosage unless directed by your healthcare practitioner.

CAUTION: If pregnant or nursing, taking other nutritional supplements or medication, consult your healthcare practitioner before use. This product contains vitamin D at a level that exceeds the adult tolerable upper intake level, the maximum daily intake unlikely to result in adverse effects in the most sensitive individuals*. Keep out of the reach of children. *Level established by the Institute of Medicine of the U.S. National Academy of Scienc

Keep in a cool, dry place, tightly capped.

DISCLAIMER: The information contained on this web site has not been evaluated by the FDA. It is not intended to treat, diagnose, cure or prevent any disease. Material on the Imupharm web site is provided for educational purposes only. Always seek the advice of your physician or other qualified health care provider with any questions you have regarding a medical condition, and before undertaking any diet, exercise or other health program.

Vitamin D has been recognized for over a century as essential for normal development and mineralization of a healthy skeleton. Most humans depend on exposure to the sun to satisfy their vitamin D requirements. Although sufficient cholecalciferol or Vitamin D3 can be obtained through brief exposure on a bright sunny day (Reference 1), it is also available orally in the form of Vitamin D3 (cholecalciferol) or D2 (ergocalciferol). Few foods naturally contain vitamin D, such as cod liver oil, salmon, and mackerel.

Mechanism of D3 production in the body through sun exposure. Skin exposure to ultraviolet B light initiates the photochemical conversion of 7-dehydrocholesterol to previtamin D3 in the epidermis and dermis. Rapid isomerization of previtamin D3 to vitamin D3 (cholecalciferol) is catalyzed via body heat, and binds to the vitamin-D-binding protein (VDBP) in the extracellular space. (Reference 2). Vitamin D3 is then transported to the liver, which uses 25-hydroxylase to produce 25-hydroxyvitamin D3, or 25(OH)D3.

Vitamin D3 and the body. Adequate circulating 25(OH)D3 are critical to maintaining the health and the functions of the immune, reproductive, muscular, skeletal and integumentary system of men and women of all ages and races. (Reference 1) In addition to bone health, there is mounting scientific evidence that suggests the relation of vitamin D deficiency to incrust risk of autoimmune disease and many common deadly cancers. (Reference 3)

Vitamin D3 and cancer.Evidence for the anticancer properties of Vitamin D has been growing and the volume of data supports a multi-pronged attack that involves growth arrest although the G1 phase of the cell cycle, apoptosis, tumor-cell differentiation, disruption of growth-factor-mediated cell survival signals, and the inhibition of angiogenesis and cell adhesion. Processes involved in the tumor suppressive activating of vitamins D analogues include inhibition of cell proliferation, induction of apoptosis, inhibition of cell adhesion, G1-phase cell-cycle arrest, promotion of cell differentiation, inhibition of angiogenesis, alteration of growth factors and inhibition of metastasis. (References 4, 5) Thus, VDR-mediated pathways constitute potential therapeutic targets for cancer prevention and treatment.

(1) Holick MF. Vitamin D: the underappreciated D-lightful hormone that is important for skeletal and cellular health. Curr Opin Endocrinol Diabetes. 2002;9:87– 98.

(2) Holick MF. Vitamin D: importance for bone health, cellular health and cancer prevention. In: Holick MF, ed. Biologic Effects of Light 2001: Proceedings of a Symposium, Boston, MA. Boston, MA: Kluwer Academic Publishing; 2002:155– 173.

(3) Mullin GE, Dobs A. Vitamin D and Its Role in Cancer and Immunity: A Prescription for Sunlight Nutr Clin Pract 2007 22: 3 305-322

(4) Gewirtz DA, Gupta MS, Sundaram S. Vitamin D3 and vitamin D3 analogues as an adjunct to cancer chemo-therapy and radiotherapy. Curr Med Chem Anticancer Agents2002 ;2:683– 690.

(5) Bohnsack BL, Hirschi KK. Nutrient regulation of cell cycle progression. Annu Rev Nutr.2004 ;24:433– 453.